Protective Effects of 3′-Epilutein and 3′-Oxolutein against Glutamate-Induced Neuronal Damage

Dietary lutein can be naturally metabolized to 3′-epilutein and 3′-oxolutein in the human body. The epimerization of happen acidic pH, through cooking, product direct oxidation retina, which is also present serum. main lutein. Thus, allylic dietary result formation 3′-oxolutein, may undergo reduction either revert or epimerize form 3′-epilutein. We focused on effects itself glutamate-induced neurotoxicity SH-SY5Y neuroblastoma cells identify possible alterations oxidative stress, inflammation, antioxidant capacity, iron metabolism that affect neurological function. ROS measurements were performed differently treated cells. inflammatory state was followed by TNFα, IL-6, IL-8 cytokine ELISA measurements. status determined total capacity kit assay. genes related ferroptosis lipid peroxidation gene expression measurements; then, thiol performed. Lutein metabolites modulated effect glutamate ROS, ferroptosis-related metabolism, Our results revealed anti-inflammatory features as protective agents against stress cells, with greater efficacy case